International Standard
ISO 10993-6:2016
Biological evaluation of medical devices — Part 6: Tests for local effects after implantation
Reference number
ISO 10993-6:2016
Edición 3
2016-12
International Standard
Vista previa
ISO 10993-6:2016
61089
No disponible en español
Publicado (Edición 3, 2016)

ISO 10993-6:2016

ISO 10993-6:2016
61089
Idioma
Formato
CHF 151
Convertir Franco suizo (CHF) a tu moneda

Resumen

ISO 10993-6:2016 specifies test methods for the assessment of the local effects after implantation of biomaterials intended for use in medical devices.

ISO 10993-6:2016 applies to materials that are

- solid and non-absorbable,

- non-solid, such as porous materials, liquids, gels, pastes, and particulates, and

- degradable and/or absorbable, which may be solid or non-solid.

The test sample is implanted into a site and animal species appropriate for the evaluation of the biological safety of the material. These implantation tests are not intended to evaluate or determine the performance of the test sample in terms of mechanical or functional loading. This part of ISO 10993 can also be applied to medical devices that are intended to be used topically in clinical indications where the surface or lining might have been breached, in order to evaluate local tissue responses.

The local effects are evaluated by a comparison of the tissue response caused by a test sample to that caused by control materials used in medical devices whose clinical acceptability and biocompatibility characteristics have been established. The objective of the test methods is to characterize the history and evolution of the tissue response after implantation of a medical device/biomaterial including final integration or absorption/degradation of the material. In particular for degradable/absorbable materials, the degradation characteristics of the material and the resulting tissue response should be determined.

ISO 10993-6:2016 does not deal with systemic toxicity, carcinogenicity, teratogenicity or mutagenicity. However, the long-term implantation studies intended for evaluation of local biological effects might provide insight into some of these properties. Systemic toxicity studies conducted by implantation might satisfy the requirements of this part of ISO 10993. When conducting combined studies for evaluating local effects and systemic effects, the requirements of both standards is to be fulfilled.

Informaciones generales

  •  : Publicado
     : 2016-12
    : Norma Internacional para revisar [90.92]
  •  : 3
     : 29
  • ISO/TC 194
    11.100.20 
  • RSS actualizaciones

Próxima versión en desarrollo

Draft International Standard
ISO/DIS 10993-6
Biological evaluation of medical devices — Part 6: Tests for local effects after implantation
Reference number
ISO/DIS 10993-6
Edición 1
Draft
International Standard

ISO/DIS 10993-6

Biological evaluation of medical devices

Part 6: Tests for local effects after implantation

ISO/DIS 10993-6

ISO/DIS 10993-6
83976
Idioma
Formato
CHF 63
Convertir Franco suizo (CHF) a tu moneda

Ciclo de vida

Got a question?

Check out our FAQs

Customer care
+41 22 749 08 88

Opening hours:
Monday to Friday - 09:00-12:00, 14:00-17:00 (UTC+1)